Topcat trial nejm
WebUsing this strategy, TOPCAT is likely to be a positive trial in patients with HFpEF and elevated BNP. One further limitation is that, for good reasons, guideline authors and regulatory agencies are reluctant to accept evidence based on a subgroup analysis based only on a segment of the trial population, even if pre-specified. Web10. apr 2014 · Aldosterone Antagonist (TOPCAT) trial is provided in the Supplementary Appen-dix, available at NEJM.org. This article was updated on April 10, 2014, at …
Topcat trial nejm
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Web17. máj 2024 · In this trial, 1,222 patients were randomly assigned to treatment with either sotagliflozin or a placebo. After a median of nine months of follow-up, treatment with sotagliflozin reduced cardiovascular deaths and hospitalizations or urgent visits for heart failure by 33% compared with placebo. WebThe CHAMPION trial will investigate the safety and clinical efficacy of the CardioMEMS hemodynamic monitoring system and may establish this management strategy as a new paradigm for the medical management of patients with symptomatic HF. CHAMPION trial rationale and design: the long-term safety and clinical efficacy of a wireless pulmonary ...
Web10. apr 2014 · Lessons from the TOPCAT Trial NEJM Home Specialties Specialties Allergy/ Immunology Cardiology Clinical Medicine Dermatology Emergency Medicine … Web24. máj 2024 · In the randomized, placebo-controlled TOPCAT study of spironolactone in patients with heart failure (HF) and preserved left ventricular ejection fraction, …
Web26. apr 2024 · In the new paper, the TOPCAT investigators analyzed stored blood samples from the trial. They found that canrenone (an active metabolite of the study drug spironolactone) concentrations were... WebSupplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Pitt B, Pfeffer MA, Assmann SF, et …
Web12. jan 2024 · EP: 21. John McMurray, MBChB: One of the large trials conducted in patients with HFpEF [heart failure with preserved ejection fraction] was the TOPCAT trial, which enrolled just under 3500 ...
Web18. nov 2013 · The TOPCAT trial showed that spironolactone is not superior to placebo in improving CV outcomes in patients with HFpEF, with higher rates of hyperkalemia and … green christmas ornaments glassWeb10. jan 2024 · The trial, sponsored by the National Institutes of Health, asked whether control of systolic hypertension in people 50 years of age or older to a target of 120 versus 140 mm Hg would result in a... green christmas pajamas for familyWebConclusions: In TOPCAT, women and men presented with different clinical profiles and similar clinical outcomes. The interaction between spironolactone and sex in TOPCAT overall and in the present analysis was nonsignificant for the primary outcome, but there was a reduction in all-cause mortality associated with spironolactone therapy in women, … flow nx2-tmWeb10. apr 2014 · Methods: In this randomized, double-blind trial, we assigned 3445 patients with symptomatic heart failure and a left ventricular ejection fraction of 45% or more to … flow nx2 hybrid snowboard bindings 2018Web6. jan 2015 · TOPCAT was an international, randomized, double-blind, placebo-controlled trial sponsored by the National Heart, Lung, and Blood Institute. TOPCAT was conducted … green christmas pillowsWeb27. sep 2024 · Explore Heart Failure articles from NEJM Evidence. current issue. View Current Issue; Browse All Issues flow nx2-tm fusionWeb4. dec 2024 · The TOPCAT trial and its design have been previously described in detail, as have its main results. 19,20 The trial was an international, multicenter, double-blinded, randomized clinical trial of the aldosterone antagonist spironolactone for patients with HFpEF, defined as symptomatic HF at the time of screening and within the preceding 12 ... flow nxt