Web1 jul. 2024 · Lipophilic statins diffuse nonselectively into extrahepatic tissues such as muscle; simvastatin, the most lipophilic statin, is most associated with muscle symptoms. Hydrophilic statins are actively transported into hepatocytes; examples are pravastatin and rosuvastatin, which are less associated with muscle symptoms. Webby pravastatin (hydrophilic statins)27. Despite of greater tissue penetration of lipophilic statins compared to hydrophilic statins; the clinical studies have not reported a great difference between the members of statins,29 21. Additionally, it has been demonstrated that hydrophilic and lipophilic statin increase NO production and
Hydrophilic or Lipophilic Statins? - ResearchGate
Web1 mrt. 2005 · Interms of lipophilic nature, lovastatin andsimvastatin are the most lipophilic, followedby atorvastatin, fluvastatin, andpravastatin. Rosuvastatin is a relativelynew … Web30 sep. 2024 · Atorvastatin is more lipophilic in comparison to other statins such as rosuvastatin. If a patient does not tolerate a statin, switching from a lipophilic to a hydrophilic or vice versa may decrease the chances of those side effects reoccurring. quantum theory of optical coherence pdf
Abstract 17590: Hydrophilic Statins Are Associated With a
Web22 jun. 2024 · Investigators also highlighted no significant differences were observed for any of the outcomes of interest based on use of hydrophilic or lipophilic statins. Further analysis suggested baseline neurocognitive function was an effect modifier for the associations of statins with dementia ( P for interaction <.001) and memory change ( P … WebHydrophilic statins (pravastatin, rosuvastatin) may cause less muscular events than lipophilic statins (e.g. simvastatin, atorva-statin) due to lower passive diffusion into muscle cells. OBJECTIVE: To compare the risk of muscular events between statins at comparable lipid-lowering doses and to evaluate if hydrophilic statins are associated … Web23 jun. 2024 · Statins are classified based on their solubility; lipophilic statins such as simvastatin and lovastatin dissolve in fats, while hydrophilic statins such as pravastatin and rosuvastatin dissolve in water. Use of any statins was associated with a 40 percent reduction in ovarian cancer mortality compared with patients who never used statins. quantum theory khan academy