Improving protein succinylation sites

Author: zsbo

August undefined, 2024

WebJun 23, 2024 · It also verified a strong correlation between gene expression and protein succinylation near the transcriptional start site by showing a correlation between the succinyl-lysine ChIP signal and gene expression, which further indicates that promoter succinylation is a mark of gene transcriptional activity. 27 Recently, it was also found that ... WebApr 23, 2024 · Using an independent test set of experimentally identified succinylation sites, our method achieved efficiency scores of 79%, 68.7% and 0.48 for sensitivity, specificity …

iSuc-ChiDT: a computational method for identifying succinylation sites …

WebAug 15, 2024 · In 2013, through the research of Park et al., 2565 protein succinylation sites were identified in 779 proteins, and their experimental results showed that the enzymes produced by lysine succinylation had potential effects on the metabolic function of mitochondria, such as the degradation of amino acids, the circulation of tricarboxylic … WebJun 1, 2024 · A total of 386 sites on 140 proteins involved in major metabolic pathways (ketogenesis, fatty acid β-oxidation, TCA cycle, and ATP-synthesis) were identified as hyper-succinylated (at least two-fold increase in succinylation as compared to WT mice) in SIRT5 knockout mice.26 Taken together, these studies suggest that succinylation is an … green folding wagon

"Improving protein succinylation sites prediction using …

WebOct 8, 2024 · Europe PMC is an archive of life sciences journal literature. WebIdentifying of post-translational modifications (PTM) is crucial in the study of computational proteomics, cell biology, pathogenesis, and drug development due to its role in many bio-molecular mechanisms. Computational methods for predicting multiple PTM ... WebApr 8, 2024 · LDHA succinylation and protein levels were analysed by immunoblotting using the indicated antibodies. C K1 cells were transfected with HA-LDHA and pCDNA-GLTC (or the empty vector control) for 48 h ... greenfold school farnworth

DeepSuccinylSite: a deep learning based approach for protein

Improving protein succinylation sites prediction using embeddings …

WebAug 18, 2024 · Abstract. Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including … WebFeb 4, 2024 · Succinylation is achieved by non-enzymatic processes or by a series of enzymes [like p300, lysine acetyltransferase 2A (KAT2A)] that transfer the succinyl groups from succinyl-coenzyme A (CoA) to the specific lysine, modulating protein function in various physiological processes [ 1 ]. flushing funeral homeWebMar 22, 2024 · Succinylation causes a protein charge flip from positive to negative and a relatively large increase in mass compared to other PTMs. Hundreds of protein succinylation sites are present in proteins of multiple tissues and species, and the significance is being actively investigated. flushing fruit down the toilet

"WebOct 8, 2024 · Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including cellular respiration, … " - Improving protein succinylation sites

Improving protein succinylation sites

Succinylation Links Metabolism to Protein Functions

WebApr 5, 2016 · Lysine succinylation is a recently discovered protein posttranslational modification and SIRT5 is an efficient desuccinylase. Although many mammalian proteins have recently been found to be regulated by lysine succinylation and SIRT5, the physiological significance of succinylation and SIRT5 remains unknown. WebNov 11, 2024 · Succinylation is an important posttranslational modification of proteins, which plays a key role in protein conformation regulation and cellular function control. Many studies have shown that succinylation modification on protein lysine residue is closely related to the occurrence of many diseases. To understand the mechanism of …

Did you know?

WebDec 27, 2024 · [Submitted on 27 Dec 2024] Predicting Succinylation Sites in Proteins with Improved Deep Learning Architecture Olusola Odeyomi, Gergely Zaruba Post-translational … WebFeb 10, 2024 · Encouraged by the successful application of the compression strategy on nucleotide sequences, we applied it to protein sequences. For the 2 × 20 contingency table for each position in succinylation site-containing sequences, the compression procedure is described below. Step 1: Set the initial value of r ( r is an integer) to 20.

WebFeb 12, 2024 · The original collection comprised 2,521 succinylation and 24,128 non-succinylation sites from 896 unique proteins. To avoid overestimations due to homology … WebProtein succinylation is a type of post-translational modification (PTM) that occurs on lysine sites and plays a key role in protein conformation regulation and cellular function control. ... “ Improving succinylation prediction accuracy by incorporating the secondary structure via helix, strand and coil, and evolutionary information from ...

WebOct 21, 2024 · Succinylation can improve the solubility of milk protein concentrate and sodium caseinate. The result of differential calorimetry scanning illustrated that the … WebSuccinylation Links Metabolism to Protein Functions. Post-translational modifications (PTMs) are important regulators of protein function, and integrate metabolism with …

WebAug 11, 2024 · Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including cellular respiration, …

WebOct 1, 2024 · As mitochondria are thought to be lysine succinylation hot spots, the proteins primarily affected by succinylation can naturally be expected to be the mitochondrial ones. However, with few exceptions ( 24, 43 ), most studies on eukaryotic succinylomes were performed on whole-cell extracts. green fold special school boltonWebFeb 1, 2024 · Of all succinylation proteins identified, 48.1% (312/649) possessed only one modified site, 21.4% (139/649) had two succinylated peptide sites, 9.9% (64/649) contained three sites, and 1.2% (8/649) of modified proteins have 10 or more sites (see Figure 1A ). The average degree of succinylation sites per protein was 2.4 (1557/649). green folding shopping cartWebImproving protein succinylation sites prediction using embeddings from protein language model Protein succinylation is an important post-translational modification (PTM) … flushing fuel systemWebLMSuccSite: Improving Protein Succinylation Sites Prediction Using Embeddings from Protein Language Model Figures Additional Declarations greenfold systems scarborough limitedWebOct 8, 2024 · Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including cellular respiration, … green fold school boltonWebJan 10, 2024 · The mole fraction of succinylation sites per protein varied from 1 to 23 (Fig. 2c and Supplementary Data 2). Our assessment found 40% (125/314) of proteins with one succinylated site, 20% (60/314 ... greenfold wayWebDownload scientific diagram Two Sample Logos of the succinylation lysine sites compared to unlabeled sites. Different color of symbles represents different physical and chemical properties ... greenfold primary school bolton