Cytoplasmic retention signal
WebJan 21, 1997 · In human cyclin B1, a cytoplasmic retention signal (CRS) has been identified that is highly conserved among B-type cyclins in higher eukaryotes. The …
Cytoplasmic retention signal
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ER retention refers to proteins that are retained in the endoplasmic reticulum, or ER, after folding; these are known as ER resident proteins. Protein localization to the ER often depends on certain sequences of amino acids located at the N terminus or C terminus. These sequences are known as signal peptides, molecular signatures, or sorting signals. WebAug 1, 1997 · The JNK signal transduction pathway is activated in response to environmental stress and by the engagement of several classes of cell surface receptors, including cytokine receptors, serpentine receptors, and receptor tyrosine kinases ( 1 ). Genetic studies of Drosophila have demonstrated that JNK is required for early …
WebNov 30, 2007 · However, cytoplasmic reaccumulation after ligand removal, although rapid for GFP-Stat3α (t ½ = 15 min), was markedly delayed for GFP-Stat3β (t ½ > 180 min). Prolonged nuclear retention of Stat3β was accompanied by reduced intranuclear mobility and increased immobile fraction. WebThe N- terminal signal/anchor of cytochrome P450 2C1 functioned as an ER retention signal when placed at the N terminus of several reporter proteins but not when fused at the C terminus of the extracellular domain of epidermal growth factor receptor, with or without a heterologous cytoplasmic domain.
WebMar 30, 2024 · The Pest-Like Sequence of IκBα Is Responsible for Inhibition of DNA Binding but Not for Cytoplasmic Retention of c-Rel or RelA Homodimers. Mary K. Ernst Laboratory of Molecular ... suggesting that it may perform the same function in cells when the activating signal is no longer present. Structurally, the human I κ Bα molecule can be divided ... WebJul 18, 2008 · The cytoplasmic tails play a role in the localization of glycosyltransferases, and coat protein complex I (COPI) vesicle–mediated retrograde transport is also involved …
WebNov 12, 2004 · Here we report that the cytoplasmic localization of hHDAC6 is resistant to treatment with leptomycin B (LMB), demonstrate that the SE14 repeat domain is responsible for this resistance, and show that hHDAC6 possesses intrinsic …
WebIntracytoplasmic protein targeting in mammalian cells is critical for organelle function as well as virus assembly, but the signals that mediate it are poorly defined. We show here that … cursed war thunderWebMar 21, 2008 · We have determined that the molecular basis for this specialized property of hA3G is a novel cytoplasmic retention signal (CRS) that is necessary and sufficient to restrict wild-type hA3G and chimeric constructs to the cytoplasm. cursed war imagesWebIn this review, the main sequence features that dictate whether any particular mRNA or lncRNA is a substrate for retention in the nucleus, or export to the cytoplasm, are … cursed warzone gunsWebMay 17, 2005 · Nucleocytoplasmic Shuttling with Periods of Retention: Smads Smad proteins are a family of inducible transcription factors that mediate signals from the transforming growth factor–β (TGF-β) superfamily of ligands, including TGF-β and bone morphogenetic protein (BMP). chartwell durham regionWebJan 21, 2024 · Misfolded and/or unassembled secretory and membrane proteins in the endoplasmic reticulum (ER) may be retro-translocated into the cytoplasm, where they undergo ER-associated degradation, or ERAD. The mechanisms by which misfolded proteins are recognized and degraded through this pathway have been studied … chartwell ecoleWebJun 7, 2007 · We will refer to this sequence as cytoplasmic localization signal (CLS). It could function as a non-canonical signal for nuclear export or as a cytoplasmic retention signal of PTEN. Mutations within the CLS induce nuclear localization and impair growth suppressive activities of PTEN while preserving lipid phosphatase activity. cursed water coolerWebApr 8, 2014 · Cytoplasmic retention of a nucleocytoplasmic protein TBC1D3 by microtubule network is required for enhanced EGFR signaling. The hominoid … cursed water ro