Cyp17a1蛋白

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August undefined, 2024

WebFunction. A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis ( PubMed: 9452426, PubMed: 27339894, PubMed: 22266943, PubMed: 25301938 ). Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an … Web进一步实验证实CPSF6是通过APA调节作用于下游靶点基因人宫颈癌癌基因2(HCCR2)，使其具有缩短3'UTR的转录本高表达，翻译更多的蛋白，进而调节肝癌的增殖和转移过程。另外，实验中发现let-7a、let-7c、miR-26a三种miRNA结合在CPSF6基因3'UTR上直接抑制基因的 …

类固醇生成因子1在孕期镉暴露抑制F1代大鼠睾酮合成中的作用及 …

Web百度百科是一部内容开放、自由的网络百科全书，旨在创造一个涵盖所有领域知识，服务所有互联网用户的中文知识性百科全书。在这里你可以参与词条编辑，分享贡献你的知识。 WebER stress增加PERK蛋白激酶活性，PERK磷酸化elF2，抑制蛋白翻译和合成，缓解ER压力。同时，elF2的磷酸化能够选择性地启动ATF4翻译，增加其结合配体的合成，影响氨基酸代谢，从而抑制蛋白的翻译和合成[6]。正常 … biological levels of organization list

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Web肾上腺皮质腺瘤CYP17A1及3BHSD2蛋白的免疫组化研究. 目的:应用免疫组织化学染色方法观察17α羟化酶 (CYP17A1),3β羟基类固醇脱氢酶2 (3BHSD2)在人正常肾上腺及其肿瘤组织中的分布特点,探讨CYP17A1,3BHSD2免疫组化检测对病理诊断肾上腺醛固酮分泌腺瘤 (APA),皮质醇分泌腺瘤 ... WebCYP21A2蛋白；细胞色素P450家族成员21B (CYP21A2)重组蛋白两个建议：. 1、用非变性纯化样品去做EK酶切、纯化。. 如果融合蛋白的降解是从N端开始的，而C端没有降解，那么应该能够拿到38肽。. 我曾经有个这么个类似情况，酶切后证实是N端降解，C端的目的蛋白好 … Web氨基酸多重序列比对显示该基因的保守区与其他物种一致。系统进化树显示,栉孔扇贝cyp17a1蛋白先与虾夷扇贝cyp17a1聚类,再与太平洋牡蛎cyp17a1以及海蜗牛cyp17a1 … dailymed bridgeport

CYP17A1 gene: MedlinePlus Genetics

WebCYP17A1 也称细胞色素 P450C17，它是一种属于 P450 细胞色素单氧酶超家族的类固醇激素合成酶 (1, 2)。. 在人体中，CYP17A1 在肾上腺皮质 … WebEach serum sample from cyp17a1 +/+ XX, cyp17a1 +/+ XY, cyp17a1 –/– XX, and cyp17a1 –/– XY fish was measured in 2 dilutions and each dilution was assayed in duplicate. All necessary reagents including buffer, standard, serum samples, tracer, and antiserum, were sequentially loaded into the corresponding wells according to the ... dailymed cangrelorWebApr 9, 2024 · 本研究主要探讨新疆阿魏中的化学物质、抗癌的作用机制及可能作用的靶点，通过网络药理学研究帮助筛选新疆阿魏的药效物质基础，对进一步研究其抗肿瘤作用单体成分及作用靶点提供理论基础。. 1方法. 1.1新疆阿魏有效成分及靶点的筛选. 利用草药-中医证候 ... biological levels of organization synonym

"Web发明领域. 本发明涉及制备苯并咪唑化合物，其用作p300和/或CBP活性调节剂和因此能够用作药物物质。发明背景 " - Cyp17a1蛋白

Cyp17a1蛋白

anti- MITF antibody--性能参数，报价/价格，图片_生物器材网

Web抗cyp17a1抗体(d-12)在各种科学出版物中有12篇引文。针对哺乳动物靶标蛋白的一抗，如抗cyp17a1 抗体 (d-12)，推荐用于检测一系列哺乳动物物种，主要有小鼠，大鼠和人物种。许多哺乳动物抗体也非常适合兽医研究，与羊、猪、羊、猫、犬、牛和马的蛋白靶点反应。 Web1.雄激素受体信号传导途径的抑制剂和p38抑制剂的药物组合，其用于治疗个体中的前列腺癌，其中前列腺肿瘤细胞表达ar-v7变体雄激素受体蛋白，或用于预防在通过雄激素受体信号传导途径的抑制剂治疗的患有前列腺癌的患者中抵抗性的发生。 2.根据权利要求1所述的用于治疗前列腺癌的药物组合 ...

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WebFeb 22, 2024 · 结构 [] 基因 []. CYP17A1 基因位于10号染色体的10q24.3带上包含有8个外显子，其cDNA全长为1527bp。. 蛋白 []. CYP17A1蛋白大小为57.4kDa ，包含有508个氨基酸残基，属于CYP450超家族，带有一个血红素相关活性位点以催化相关生物反应。. CYP17A1可被两种甾类抑制剂阿比特龙（英语： abiraterone ）和galeterone特异 ... Web摘要：第一部分类固醇生成因子1(SF-1)在孕期镉暴露抑制F1代大鼠睾酮合成中的作用及其表观遗传机制研究目的:探究孕期镉暴露对F1代大鼠睾丸发育及类固醇激素合成的影响,以及SF-1调控类固醇激素合成相关因子表达在孕期镉暴露影响F1代大鼠睾酮合成中作用及其表观遗传机制.方法:将40只成年SD孕鼠 ...

Web重组蛋白：多项发明专利，真核、原核表达系统稳定表达3000余种蛋白，生物活性良好；产品定制： ELISA试剂盒、抗体、重组蛋白根据您需求可提供专业定制服务。 http://kns55.zh.eastview.com/kcms/detail/detailall.aspx?filename=1021623197.nh&dbcode=CMFD&dbname=CMFDTEMP

CYP17A1 is a 57.4 kDa protein that belongs to the cytochrome P450 family. The protein encoded by its cDNA is composed of 508 amino acid residues. As an enzyme, CYP17A1 possesses an active site that associates with a heme prosthetic group to catalyze biosynthetic reactions. See more Cytochrome P450 17A1 (steroid 17α-monooxygenase, 17α-hydroxylase, 17-alpha-hydroxylase, 17,20-lyase, 17,20-desmolase) is an enzyme of the hydroxylase type that in humans is encoded by the … See more Gene The CYP17A1 gene resides on chromosome 10 at the band 10q24.3 and contains 8 exons. The cDNA of this gene spans a length of 1527 bp. This gene encodes a member of the cytochrome P450 superfamily … See more CYP17A1 is a member of the cytochrome P450 superfamily of enzymes localized in the endoplasmic reticulum. Proteins in this family are monooxygenases that catalyze synthesis of cholesterol, steroids and other lipids and are involved in drug metabolism. CYP17A1 has both … See more • Pregnenolone • 17α-Hydroxypregnenolone • Progesterone • 17α-Hydroxyprogesterone See more Expression of CYP17A1 has been found in all of the traditional steroidogenic tissues except the placenta, including the zona reticularis and zona fasciculata of the adrenal cortex, the Leydig cells of the testes, the thecal cells of the ovaries, and, more recently, in See more Mutations in this gene are associated with rare forms of congenital adrenal hyperplasia, specifically 17α-hydroxylase deficiency/17,20-lyase deficiency and isolated 17,20-lyase deficiency See more CYP17A1 inhibitors Currently, the FDA has approved only one CYP17A1 inhibitor, abiraterone, which contains a steroidal … See more WebPROTAC Linker-德尔塔(Delta) - 专注化学试剂、生物试剂、分析试剂等研发用试剂知名品牌！定制生产，产品长期供货。PROTAC Linker-德尔塔(Delta) - 专注化学试剂、生物试剂、分析试剂等研发用试剂知名品牌！仅用于科研。PROTAC Linker-德尔塔(Delta) - 专注化学试剂、生物试剂、分析试剂等研发用试剂知名品牌！

Web新冠病毒结构蛋白表达质粒新冠病毒重组蛋白新冠病毒结构蛋白抗体主蛋白酶相关 ace2相关炎症和免疫反应监测 covid-19 药物研发 > 蛋白酶蛋白酶荧光底物抑制剂筛选试剂盒 fda批准药物库化合物 covid-19 相关仪器 > 仪器 covid-19 技术服务 > 服务

Webcyp11b2编码一种多功能蛋白酶，兼具11β-羟化酶、18-羟化酶、18氧化酶和醛固酮合成酶活性。（3）cyp17a1（p450c17）基因：人类cyp17a1基因定位于10q24.3，包含8个外显子和7个内含子，基因全长6.6kb。cyp17a1编码的蛋白酶兼具17α-羟化酶和17，20-裂解酶的活性。 biological levels of hierarchyWebJan 22, 2012 · Cytochrome P450 17A1 (also known as CYP17A1 and cytochrome P450c17) catalyses the biosynthesis of androgens in humans. As prostate cancer cells proliferate in response to androgen steroids, CYP17A1 inhibition is a new strategy to prevent androgen synthesis and treat lethal metastatic castration-resistant prostate cancer, but drug … biological levels in orderWeb目的探讨细胞色素P450c17a酶 (CYP17A1)在人神经胶质瘤细胞系T98G,U87和U251中的表达情况.方法采用Western blot和实时荧光定量PCR于蛋白质水平和mRNA水平检测细胞色素P450c17a酶 (CYP17A1)在三种人胶质瘤细胞系中的表达.结果 Western blot检测出CYP17A1蛋白在胶质瘤细胞系T98G,U251和 ... biological levels of organization simulationWebThe CYP17A1 gene provides instructions for making a member of the cytochrome P450 enzyme family. Like other cytochrome P450 enzymes, CYP17A1 is involved in the … biological levels of organization non exampleWebMar 21, 2024 · CYP11A1 (Cytochrome P450 Family 11 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP11A1 include Adrenal Insufficiency, Congenital, With 46,Xy Sex Reversal, … biological life boot loaderWebDefects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5) [MIM:202410]. AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to … biological light bulbWeb使用 cyp17a1 (e6y3s) 兔单克隆抗体对人肾上腺皮质的提取物进行蛋白印迹分析。对小鼠睾丸提取物 CYP17A1 进行免疫沉淀。泳道 1 为 10% 输入，泳道 2 为兔 (DA1E) 单克隆抗体 IgG XP ® 同型对照 #3900，泳道 3 … biological lifeforms