Cholesterol homeostasis gsea

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August undefined, 2024

WebDec 23, 2015 · CHOLESTEROL_HOMEOSTASIS: metabolic: cholesterol homeostasis: 28: 74: 22: FATTY_ACID_METABOLISM: metabolic: fatty acid metabolism: 53: 158: 23: … WebBackground: Endometrial cancer (EC) is one of the most common gynecological malignancies in women. Cholesterol metabolism has been confirmed to be closely related to tumor proliferation, invasion and metastasis. However, the correlation between cholesterol homeostasis-related genes and prognosis of EC remains unclear.Methods: …

RORγ is a targetable master regulator of cholesterol ... - PubMed

WebCholesterol metabolism is altered to enhance the senescence-associated secretory phenotype a, GSEA of differentially expressed genes with a focus on metabolic pathways during DNA damage-induced ... mumble vs discord reddit

Fine‐Tuning of Cholesterol Homeostasis Controls Erythroid ...

WebMar 17, 2024 · The analysis with GO, KEGG, and GSEA pathways was enriched in cholesterol metabolism, regulation of lipolysis in adipocytes, and amino acid metabolism. ... Interestingly, studies have shown that the dysregulation of intracellular calcium homeostasis in cardiac myocytes is an important factor in exacerbating the … WebNov 1, 2024 · Conclusion: We constructed and validated a cholesterol homeostasis-related gene signature to predict the prognosis of EC, which correlated to immune infiltration and expected to help the diagnosis ... WebFeb 10, 2024 · b Enrichment plot of the cholesterol homeostasis pathway after ENSA knockdown in MDA-MB-231 cells. ... GSEA gene set enrichment analysis, NES normalized enrichment score. mumbly and muttley

Mechanisms and regulation of cholesterol homeostasis

A Novel Role of SMG1 in Cholesterol Homeostasis That Depends …

WebNov 5, 2024 · To investigate the roles of cholesterol homeostasis in terminal erythropoiesis, we used a well-established ex vivo mouse fetal liver cell culture system, in which TER119-negative erythroblasts isolated from E14.5 fetal liver (FLCs) were differentiated into enucleated reticulocytes in vitro. ... GSEA of the transcriptome … WebNov 10, 2024 · Cholesterol homeostasis is essential for health. Cholesterol serves as a precursor of various steroid hormones, bile acids, and vitamin D. Besides, cholesterol is an essential component of cell membrane and provides lipid for cell proliferation. mumbly showWebApr 9, 2012 · Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipid-loaded macrophages in the arterial wall. We demonstrate that macrophage lipid body formation can be... mumbly\u0027s laugh

"WebThe gene set enrichment analysis (GSEA) analysis further supported that Setd2 KO tissues had lower expression of cholesterol homeostasis genes, both in normal liver and tumor tissues (Fig. 3B,C). Considering the increased liver weight and liver/body weight ratio of Setd2 cKO mice (Figs. 2D and 3D), we hypothesized that Setd2 may regulate lipid ... " - Cholesterol homeostasis gsea

Cholesterol homeostasis gsea

Frontiers Cholesterol Metabolism: A Double-Edged Sword in ...

WebNov 28, 2024 · Moreover, GSEA showed that 24OHC was associated with positive regulation of cholesterol efflux, but negatively associated with gene signatures linked to cholesterol homeostasis, SREBP targets and stem cell proliferation (Fig 5D). A volcano plot of the RNA-seq results revealed significant changes in several target genes of two … WebJul 15, 2024 · GOBP_LIPID_HOMEOSTASIS: Systematic name: M12045: Brief description: Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. [GOC:BHF, GOC:rl] Full description or abstract : Collection: C5: Ontology GO: Gene Ontology GO:BP: GO Biological Process: Source publication : Exact source: …

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WebCholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed cholesterol balance underlies not only cardiovascular disease but also an increasing number of other diseases such as neurodegenerative diseases and cancers. The cellular cholesterol level reflects the dynamic bal … WebApr 6, 2024 · Pathway analysis revealed that fatty acid metabolism, cholesterol homeostasis, and mitochondrial functions were top enriched signatures in CD70 …

WebJan 4, 2024 · Our observations show that modulation of cholesterol homeostasis is a major effect of necrotic cell debris and STING and suggest that combining STING agonists with statins may help control tumor growth. ... Gene Set Enrichment Analysis (GSEA) ... WebSep 6, 2024 · Decreased cholesterol homeostasis signature in MDA-MB-231 PKM2 KO cells. Cholesterol homeostasis signature was generated by GSEA (v4.1.0) with adjusted P-value and normalized enrichment score …

WebCholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed cholesterol balance underlies not only cardiovascular disease but also an increasing … WebDec 17, 2024 · Cholesterol homeostasis at systemic levels requires collaboration between various tissues, which ensures a balance between cholesterol absorption (in the …

Web1. Introduction. Cholesterol is a unique lipid that plays an essential role in membrane biogenesis. In mammals, cholesterol is principally obtained from diet and de novo biosynthesis by the liver and is distributed throughout the body via low-density lipoprotein (LDL) and high-density lipoprotein [1].Nowadays, due to overnutrition and sedentary …

WebWe now describe a new YAP-independent role for LATS2 in regulating cholesterol homeostasis by restricting the activity of SREBPs, master regulators of cholesterol and lipid metabolism. ... GSEA of the most differentially expressed (fold change >1.5; P-value < 0.05) genes between the livers of wild-type and Lats2-CKO mice fed an HCD, ... mumbly\u0027s off road incWeba, GSEA of differentially expressed genes in human OA for the cholesterol homeostasis pathway (left, top) and the mTOR signaling pathway (left, bottom). False discovery rate (q-value) and ... mumbo jumbo fan art hermitcraftWebApr 10, 2024 · Since Srebp1 is a master transcription factor for cholesterol synthesis, this increase was potentially due to a compensatory effect on cholesterol production. For lipid degradation pathways, strong decreases in β-oxidation genes were observed in Irs1 and Bcl6 KO livers ( Figure 6 F, upper panel), likely because these livers had the least ... mumbly characterWebDec 23, 2015 · The Molecular Signatures Database (MSigDB) is one of the most widely used and comprehensive databases of gene sets for performing gene set enrichment analysis. Since its creation, MSigDB has grown beyond its roots in metabolic disease and cancer to include >10,000 gene sets. These better represen … mumbo chicken wingsWebJul 2, 2024 · A Novel Role of SMG1 in Cholesterol Homeostasis That Depends Partially on p53 Alternative Splicing by Muyang Li 1,*, Fredrick Philantrope 1, Alexandra Diot 2, Jean-Christophe Bourdon 2 and Patricia Thompson 1,* 1 Department of Pathology, Renaissance School of Medicine, Stony Brook University, New York, NY 11794, USA 2 mumbo holding shift with his thumbWebPancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with a dismal prognosis. PDAC have extensively reprogrammed metabolic characteristics influenced by interactions with normal cells, the effects of the tumor microenvironment and oncogene-mediated cell-autonomous pathways. In this study, we found that among all cancer hallmarks, … mumbo jumbo hermitcraft 8 ep 12Webv. t. e. In biology, homeostasis ( British also homoeostasis) (/hɒmɪə (ʊ)ˈsteɪsɪs/) is the state of steady internal, physical, and chemical conditions maintained by living systems. [1] This is the condition of optimal … mumbo jumbo hermitcraft 8 ep 29