Bivalirudin renal or liver clearance
WebOct 17, 2024 · As patients transition between dialysis modalities, and from the intra- to the inter-dialytic period, medications with a narrow therapeutic index that are cleared in …
Bivalirudin renal or liver clearance
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WebClearance is reduced approximately 20% in patients with moderate and severe renal impairment and by 80% in dialysis-dependent patients; Bivalirudin is hemodialyzable … WebSep 15, 2024 · The clearance of bivalirudin was reduced approximately 20% in patients with moderate and severe renal impairment and was reduced approximately 80% in …
WebTsu LV and Dager WE. Bivalirudin dosing adjustments for reduced renal function with or without hemodialysis in the management of heparin-induced thrombocytopenia. Ann Pharmacother 2011; 45(10):1185-92. Runyan CL et al. Correlation of bivalirudin dose with creatinine clearance during treatment of heparin-induced thrombocytopenia. Web2.2 Dose Adjustment in Renal Impairment Bolus Dose No reduction in the bolus dose is needed for any degree of renal impairment. Maintenance Infusion In patients with creatinine clearance less than 30 mL/min (by Cockcroft Gault equation), reduce the infusion rate to 1 mg/kg/h. Monitor anticoagulant status in patients with renal impairment.
WebThe disposition of bivalirudin was studied in PTCA patients with mild, moderate and severe renal impairment. The clearance of bivalirudin was reduced approximately 21% in patients with moderate and severe renal impairment and was reduced approximately 70% in dialysis-dependent patients [see Clinical Pharmacology (12.3)]. WebBivalirudin is a 20 amino-acids hirudin-analogue with a molecular mass of 2’180 Da and a half-life of ~25 minutes; it is eliminated by proteolysis and for ~20% by renal clearance . Both bind human thrombin reversibly, …
WebBivalirudin is administered via continuous intravenous infusion, is removed by a combination of proteolytic cleavage by thrombin and renal clearance mechanisms, and can inhibit both soluble and clot-bound thrombin. ... Bivalirudin concentration may be affected by drug interactions, liver, and renal disease.
WebJul 25, 2024 · The average duration of heparin therapy prior to starting bivalirudin was 8 days (range: 1-26 days), with bivalirudin being utilized for a median of 9.5 days and … raymond price pa idaho fallsWebJan 12, 2024 · Bivalirudin does not bind to plasma proteins (other than thrombin) or to red blood cells. Elimination. Bivalirudin has a half-life of 25 minutes in PTCA patients with normal renal function. The total body … raymond price pennWebAug 22, 2024 · This precaution is based on adult studies of patients with these disease states who had reduced argatroban clearance. Renal Dose Adjustments. No adjustment recommended. Liver Dose Adjustments. Moderately impaired hepatic function: Initial: 0.5 mcg/kg/min administered as a constant infusion. raymond price nixonWebweight heparin and patients with impaired renal function will either have a contraindication to medications or need to have doses adjusted based on creatinine clearance. For example a patient with a creatinine clearance < 30 mL/min would not be a candidate for fondaparinux, but the LMWHs may be used if the dose is adjusted. simplify 15 - 12 - 8 + 4 - 6 + 1WebApr 30, 2015 · - Advantages and disadvantages of oral anticoagulants - LMW heparin dosing renal insufficiency (adults) - Anticoagulant dose adjustment in liver disease - Possible contraindications to anticoagulation - Standard dosing of DOACs - DOACs PK and drug interactions - Inhibitors and inducers of P-glycoprotein drug efflux - DOAC … simplify -15/18WebMay 1, 2024 · Unlike argatroban, bivalirudin is not Food and Drug Administration (FDA)-approved for HIT but is commonly used off-label with a recommended initial dose 0.15 to 0.2 mg/kg/h in patients with normal … simplify 15 - 12 - 8 + 4 - 6 + 1 -4 -6 4WebAlthough its clearance is largely organ independent (blood proteases), the kidneys provide approximately 20% of its clearance necessitating dose adjustments with moderate renal insufficiency and its molecular properties facilitate clearance with hemodialysis. 5 Unlike the heparin–antithrombin III complex, bivalirudin exerts its effect by ... raymond priester